Contact Information

Jacco de Zwart
(Jacobus Adrianus de Zwart)
10 Center Dr.
Bldg. 10, Rm. B1D-726 - MSC 1065
Bethesda, MD 20892-1065
USA
Tel.: +1 301 594 7315
Fax: +1 301 480 2558
E-mail: Jacco.deZwart at nih . gov

Positions

Education

• Ph.D.:
  • Université Victor Segalen Bordeaux II, Bordeaux, France, Biologie Santé (Medical Biology), February 4, 2000
  • Universiteit Utrecht, Utrecht, the Netherlands, Geneeskunde (Medicine), May 24, 2000
  - Based on a joint thesis agreement with Université Victor Segalen
  - Dissertation entitled: "Fast magnetic resonance temperature imaging for control of localized hyperthermia in medicine" ISBN 90-393-2362-3, Numéro national de thèse 2000BOR28713
• M.Sc.:
  • Moleculaire Wetenschappen (Molecular Sciences), Landbouwuniversiteit Wageningen (WAU), Wageningen, the Netherlands, July 1995
  - Masters' Theses:
  
  • "Fast MRI thermometry", In Vivo NMR Research Center (NCRR, NIH, Bethesda, MD, USA), July 1995
  • "Time resolved imaging microscopy in Wageningen", Department of Biochemistry (WAU), December 1994
  • "Diffusie en perfusiemetingen - PFG NMR & NMR imaging" (in Dutch), Department of Molecular Physics (WAU), January 1994

Publications

• JA de Zwart, P van Gelderen, Y Wang, JH Duyn
  Accelerated multislice MRI with patterned excitation.
  Magn Reson Med 2024 91:252-265


• ES Beck, WA Mullins, J Dos Santos Silva, S Filippini, P Parvathaneni, J Maranzano, M Morrison, DJ Suto, C Donnay, H Dieckhaus, NJ Luciano, K Sharma, MI Gaitán, J Liu, JA de Zwart, P van Gelderen, I Cortese, S Narayanan, JH Duyn, G Nair, P Sati, DS Reich
  Cortical lesions uniquely predict motor disability accrual and form rarely in the absence of new white matter lesions in multiple sclerosis.
  medRxiv 2023 :
• P van Gelderen, X Li, JA de Zwart, ES Beck, SV Okar, Y Huang, K Lai, J Sulam, PCM van Zijl, DS Reich, JH Duyn, J Liu
  Effect of motion, cortical orientation and spatial resolution on quantitative imaging of cortical R(2)* and magnetic susceptibility at 0.3 mm in-plane resolution at 7 T.
  Neuroimage 2023 270:119992


• ES Beck, J Maranzano, NJ Luciano, P Parvathaneni, S Filippini, M Morrison, DJ Suto, T Wu, P van Gelderen, JA de Zwart, S Antel, D Fetco, J Ohayon, F Andrada, Y Mina, C Thomas, S Jacobson, J Duyn, I Cortese, S Narayanan, G Nair, P Sati, DS Reich
  Cortical lesion hotspots and association of subpial lesions with disability in multiple sclerosis.
  Mult Scler 2022 28:1351-1363
• Y Wang, P van Gelderen, JA de Zwart, PS Özbay, H Mandelkow, D Picchioni, JH Duyn
  Cerebrovascular activity is a major factor in the cerebrospinal fluid flow dynamics.
  Neuroimage 2022 258:119362
• F La Rosa, ES Beck, J Maranzano, RA Todea, P van Gelderen, JA de Zwart, NJ Luciano, JH Duyn, JP Thiran, C Granziera, DS Reich, P Sati, M Bach Cuadra
  Multiple sclerosis cortical lesion detection with deep learning at ultra-high-field MRI.
  NMR Biomed 2022 35:e4730
• D Picchioni, PS Özbay, H Mandelkow, JA de Zwart, Y Wang, P van Gelderen, JH Duyn
  Autonomic arousals contribute to brain fluid pulsations during sleep.
  Neuroimage 2022 249:118888


• JA de Zwart, P van Gelderen, JH Duyn
  Sensitivity limitations of high-resolution perfusion-based human fMRI at 7 Tesla.
  Magn Reson Imaging 2021 84:135-144
• SE Goodale, N Ahmed, C Zhao, JA de Zwart, PS Özbay, D Picchioni, J Duyn, DJ Englot, VL Morgan, C Chang
  fMRI-based detection of alertness predicts behavioral response variability.
  Elife 2021 10:e62376
• J Liu, ES Beck, S Filippini, P van Gelderen, JA de Zwart, G Norato, P Sati, O Al-Louzi, H Kolb, M Donadieu, M Morrison, JH Duyn, DS Reich
  Navigator-Guided Motion and B0 Correction of T2*-Weighted Magnetic Resonance Imaging Improves Multiple Sclerosis Cortical Lesion Detection.
  Invest Radiol 2021 56:409-416
• Y Wang, P van Gelderen, JA de Zwart, AE Campbell-Washburn, JH Duyn
  FMRI based on transition-band balanced SSFP in comparison with EPI on a high-performance 0.55 T scanner.
  Magn Reson Med 2021 85:3196-3210


• J Liu, P van Gelderen, JA de Zwart, JH Duyn
  Reducing motion sensitivity in 3D high-resolution T₂*-weighted MRI by navigator-based motion and nonlinear magnetic field correction.
  Neuroimage 2020 206:116332
• N Gudino, JA de Zwart, JH Duyn
  Eight-channel parallel transmit-receive system for 7 T MRI with optically controlled and monitored on-coil current-mode RF amplifiers.
  Magn Reson Med 2020 84:3494-3501
• Y Wang, P van Gelderen, JA de Zwart, JH Duyn
  B₀-field dependence of MRI T₁ relaxation in human brain.
  Neuroimage 2020 213:116700


• TM Moehlman, JA de Zwart, MG Chappel-Farley, X Liu, IB McClain, C Chang, H Mandelkow, PS Özbay, NL Johnson, RE Bieber, KA Fernandez, KA King, CK Zalewski, CC Brewer, P van Gelderen, JH Duyn, D Picchioni
  All-night functional magnetic resonance imaging sleep studies.
  J Neurosci Methods 2019 316:83-98


• X Liu, JA de Zwart, ML Schölvinck, C Chang, FQ Ye, DA Leopold, JH Duyn
  Subcortical evidence for a contribution of arousal to fMRI studies of brain activity.
  Nat Commun 2018 9:395
• PS Özbay, C Chang, D Picchioni, H Mandelkow, TM Moehlman, MG Chappel-Farley, P van Gelderen, JA de Zwart, JH Duyn
  Contribution of systemic vascular effects to fMRI activity in white matter.
  Neuroimage 2018 176:541-549
• JA de Zwart, P van Gelderen, MK Schindler, P Sati, J Liu, DS Reich, JH Duyn
  Impulse response timing differences in BOLD and CBV weighted fMRI.
  Neuroimage 2018 181:292-300
• C Ianniello, JA de Zwart, Q Duan, CM Deniz, L Alon, JS Lee, R Lattanzi, R Brown
  Synthesized tissue-equivalent dielectric phantoms using salt and polyvinylpyrrolidone solutions.
  Magn Reson Med 2018 80:413-419
• J Liu, JA de Zwart, P van Gelderen, J Murphy-Boesch, JH Duyn
  Effect of head motion on MRI B₀ field distribution.
  Magn Reson Med 2018 80:2538-2548
• N Gudino, JA de Zwart, Q Duan, SJ Dodd, J Murphy-Boesch, P van Gelderen, JH Duyn
  Optically controlled on-coil amplifier with RF monitoring feedback.
  Magn Reson Med 2018 79:2833-2841


• H Mandelkow, JA de Zwart, JH Duyn
  Effects of spatial fMRI resolution on the classification of naturalistic movies.
  Neuroimage 2017 162:45-55


• H Mandelkow, JA de Zwart, JH Duyn
  Linear Discriminant Analysis Achieves High Classification Accuracy for the BOLD fMRI Response to Naturalistic Movie Stimuli.
  Front Hum Neurosci 2016 10:128
• N Gudino, Q Duan, JA de Zwart, J Murphy-Boesch, SJ Dodd, H Merkle, P van Gelderen, JH Duyn
  Optically controlled switch-mode current-source amplifiers for on-coil implementation in high-field parallel transmission.
  Magn Reson Med 2016 76:340-9


• P van Gelderen, H Mandelkow, JA de Zwart, JH Duyn
  A torque balance measurement of anisotropy of the magnetic susceptibility in white matter.
  Magn Reson Med 2015 74:1388-96
• X Li, P van Gelderen, P Sati, JA de Zwart, DS Reich, JH Duyn
  Detection of demyelination in multiple sclerosis by analysis of [Formula: see text] relaxation at 7 T.
  Neuroimage Clin 2015 7:709-14
• Q Duan, G Nair, N Gudino, JA de Zwart, P van Gelderen, J Murphy-Boesch, DS Reich, JH Duyn, H Merkle
  A 7T spine array based on electric dipole transmitters.
  Magn Reson Med 2015 74:1189-97


• Q Duan, JH Duyn, N Gudino, JA de Zwart, P van Gelderen, DK Sodickson, R Brown
  Characterization of a dielectric phantom for high-field magnetic resonance imaging applications.
  Med Phys 2014 41:102303
• Z Liu, JA de Zwart, C Chang, Q Duan, P van Gelderen, JH Duyn
  Neuroelectrical decomposition of spontaneous brain activity measured with functional magnetic resonance imaging.
  Cereb Cortex 2014 24:3080-9
• MG Bright, M Bianciardi, JA de Zwart, K Murphy, JH Duyn
  Early anti-correlated BOLD signal changes of physiologic origin.
  Neuroimage 2014 87:287-96


• JA de Zwart, P van Gelderen, Z Liu, JH Duyn
  Independent sources of spontaneous BOLD fluctuation along the visual pathway.
  Brain Topogr 2013 26:525-37
• JM Jansma, JA de Zwart, P van Gelderen, JH Duyn, WC Drevets, ML Furey
  In vivo evaluation of the effect of stimulus distribution on FIR statistical efficiency in event-related fMRI.
  J Neurosci Methods 2013 215:190-5
• P Sati, P van Gelderen, AC Silva, DS Reich, H Merkle, JA de Zwart, JH Duyn
  Micro-compartment specific T2* relaxation in the brain.
  Neuroimage 2013 77:268-78


• Z Liu, JA de Zwart, P van Gelderen, LW Kuo, JH Duyn
  Statistical feature extraction for artifact removal from concurrent fMRI-EEG recordings.
  Neuroimage 2012 59:2073-87
• Z Liu, JA de Zwart, B Yao, P van Gelderen, LW Kuo, JH Duyn
  Finding thalamic BOLD correlates to posterior alpha EEG.
  Neuroimage 2012 63:1060-9
• P van Gelderen, JA de Zwart, J Lee, P Sati, DS Reich, JH Duyn
  Nonexponential T₂ decay in white matter.
  Magn Reson Med 2012 67:110-7


• M Freed, JA de Zwart, P Hariharan, MR Myers, A Badano
  Development and characterization of a dynamic lesion phantom for the quantitative evaluation of dynamic contrast-enhanced MRI.
  Med Phys 2011 38:5601-11
• S Wang, JA de Zwart, JH Duyn
  A fast integral equation method for simulating high-field radio frequency coil arrays in magnetic resonance imaging.
  Phys Med Biol 2011 56:2779-89
• M Freed, JA de Zwart, JT Loud, RH El Khouli, KJ Myers, MH Greene, JH Duyn, A Badano
  An anthropomorphic phantom for quantitative evaluation of breast MRI.
  Med Phys 2011 38:743-53
• M Bianciardi, M Fukunaga, P van Gelderen, JA de Zwart, JH Duyn
  Negative BOLD-fMRI signals in large cerebral veins.
  J Cereb Blood Flow Metab 2011 31:401-12


• Z Liu, M Fukunaga, JA de Zwart, JH Duyn
  Large-scale spontaneous fluctuations and correlations in brain electrical activity observed with magnetoencephalography.
  Neuroimage 2010 51:102-11
• M Fukunaga, TQ Li, P van Gelderen, JA de Zwart, K Shmueli, B Yao, J Lee, D Maric, MA Aronova, G Zhang, RD Leapman, JF Schenck, H Merkle, JH Duyn
  Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast.
  Proc Natl Acad Sci U S A 2010 107:3834-9


• M Bianciardi, M Fukunaga, P van Gelderen, SG Horovitz, JA de Zwart, K Shmueli, JH Duyn
  Sources of functional magnetic resonance imaging signal fluctuations in the human brain at rest: a 7 T study.
  Magn Reson Imaging 2009 27:1019-29
• B Yao, TQ Li, Pv Gelderen, K Shmueli, JA de Zwart, JH Duyn
  Susceptibility contrast in high field MRI of human brain as a function of tissue iron content.
  Neuroimage 2009 44:1259-66
• K Shmueli, JA de Zwart, P van Gelderen, TQ Li, SJ Dodd, JH Duyn
  Magnetic susceptibility mapping of brain tissue in vivo using MRI phase data.
  Magn Reson Med 2009 62:1510-22
• M Bianciardi, M Fukunaga, P van Gelderen, SG Horovitz, JA de Zwart, JH Duyn
  Modulation of spontaneous fMRI activity in human visual cortex by behavioral state.
  Neuroimage 2009 45:160-8
• L Qin, P van Gelderen, JA Derbyshire, F Jin, J Lee, JA de Zwart, Y Tao, JH Duyn
  Prospective head-movement correction for high-resolution MRI using an in-bore optical tracking system.
  Magn Reson Med 2009 62:924-34
• M Papoutsi, JA de Zwart, JM Jansma, MJ Pickering, JA Bednar, B Horwitz
  From phonemes to articulatory codes: an fMRI study of the role of Broca's area in speech production.
  Cereb Cortex 2009 19:2156-65
• JA de Zwart, P van Gelderen, JM Jansma, M Fukunaga, M Bianciardi, JH Duyn
  Hemodynamic nonlinearities affect BOLD fMRI response timing and amplitude.
  Neuroimage 2009 47:1649-58
• M Bianciardi, P van Gelderen, JH Duyn, M Fukunaga, JA de Zwart
  Making the most of fMRI at 7 T by suppressing spontaneous signal fluctuations.
  Neuroimage 2009 44:448-54


• JA de Zwart, Pv Gelderen, M Fukunaga, JH Duyn
  Reducing correlated noise in fMRI data.
  Magn Reson Med 2008 59:939-45
• SG Horovitz, M Fukunaga, JA de Zwart, P van Gelderen, SC Fulton, TJ Balkin, JH Duyn
  Low frequency BOLD fluctuations during resting wakefulness and light sleep: a simultaneous EEG-fMRI study.
  Hum Brain Mapp 2008 29:671-82
• P van Gelderen, JA de Zwart, JH Duyn
  Pittfalls of MRI measurement of white matter perfusion based on arterial spin labeling.
  Magn Reson Med 2008 59:788-95
• M Fukunaga, SG Horovitz, JA de Zwart, P van Gelderen, TJ Balkin, AR Braun, JH Duyn
  Metabolic origin of BOLD signal fluctuations in the absence of stimuli.
  J Cereb Blood Flow Metab 2008 28:1377-87


• K Shmueli, P van Gelderen, JA de Zwart, SG Horovitz, M Fukunaga, JM Jansma, JH Duyn
  Low-frequency fluctuations in the cardiac rate as a source of variance in the resting-state fMRI BOLD signal.
  Neuroimage 2007 38:306-20
• JM Jansma, NF Ramsey, JA de Zwart, P van Gelderen, JH Duyn
  fMRI study of effort and information processing in a working memory task.
  Hum Brain Mapp 2007 28:431-40
• JH Duyn, P van Gelderen, TQ Li, JA de Zwart, AP Koretsky, M Fukunaga
  High-field MRI of brain cortical substructure based on signal phase.
  Proc Natl Acad Sci U S A 2007 104:11796-801
• P van Gelderen, JA de Zwart, P Starewicz, RS Hinks, JH Duyn
  Real-time shimming to compensate for respiration-induced B0 fluctuations.
  Magn Reson Med 2007 57:362-8


• RH Deckers, P van Gelderen, M Ries, O Barret, JH Duyn, VN Ikonomidou, M Fukunaga, GH Glover, JA de Zwart
  An adaptive filter for suppression of cardiac and respiratory noise in MRI time series data.
  Neuroimage 2006 33:1072-81
• JA de Zwart, P van Gelderen, X Golay, VN Ikonomidou, JH Duyn
  Accelerated parallel imaging for functional imaging of the human brain.
  NMR Biomed 2006 19:342-51
• M Fukunaga, SG Horovitz, P van Gelderen, JA de Zwart, JM Jansma, VN Ikonomidou, R Chu, RH Deckers, DA Leopold, JH Duyn
  Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages.
  Magn Reson Imaging 2006 24:979-92
• JA de Zwart, P van Gelderen, JH Duyn
  Receive coil arrays and parallel imaging for functional magnetic resonance imaging of the human brain.
  Conf Proc IEEE Eng Med Biol Soc 2006 2006:17-20


• VN Ikonomidou, P van Gelderen, JA de Zwart, M Fukunaga, JH Duyn
  Optimizing brain tissue contrast with EPI: a simulated annealing approach.
  Magn Reson Med 2005 54:373-85
• P van Gelderen, C W H Wu, JA de Zwart, L Cohen, M Hallett, JH Duyn
  Resolution and reproducibility of BOLD and perfusion functional MRI at 3.0 Tesla.
  Magn Reson Med 2005 54:569-76
• JA de Zwart, AC Silva, P van Gelderen, P Kellman, M Fukunaga, R Chu, AP Koretsky, JA Frank, JH Duyn
  Temporal dynamics of the BOLD fMRI impulse response.
  Neuroimage 2005 24:667-77
• JH Duyn, P van Gelderen, L Talagala, A Koretsky, JA de Zwart
  Technological advances in MRI measurement of brain perfusion.
  J Magn Reson Imaging 2005 22:751-3


• R Chu, JA de Zwart, P van Gelderen, M Fukunaga, P Kellman, T Holroyd, JH Duyn
  Hunting for neuronal currents: absence of rapid MRI signal changes during visual-evoked response.
  Neuroimage 2004 23:1059-67
• JA de Zwart, PJ Ledden, P van Gelderen, J Bodurka, R Chu, JH Duyn
  Signal-to-noise ratio and parallel imaging performance of a 16-channel receive-only brain coil array at 3.0 Tesla.
  Magn Reson Med 2004 51:22-6
• J Bodurka, PJ Ledden, P van Gelderen, R Chu, JA de Zwart, D Morris, JH Duyn
  Scalable multichannel MRI data acquisition system.
  Magn Reson Med 2004 51:165-71
• X Golay, JA de Zwart, YC Ho, YY Sitoh
  Parallel imaging techniques in functional MRI.
  Top Magn Reson Imaging 2004 15:255-65


• P Kellman, Pv Gelderen, JA de Zwart, JH Duyn
  Method for functional MRI mapping of nonlinear response.
  Neuroimage 2003 19:190-9
• E Guilhon, P Voisin, JA de Zwart, B Quesson, R Salomir, C Maurange, V Bouchaud, P Smirnov, H de Verneuil, A Vekris, P Canioni, CT Moonen
  Spatial and temporal control of transgene expression in vivo using a heat-sensitive promoter and MRI-guided focused ultrasound.
  J Gene Med 2003 5:333-42


• B Quesson, F Vimeux, R Salomir, JA de Zwart, CT Moonen
  Automatic control of hyperthermic therapy based on real-time Fourier analysis of MR temperature maps.
  Magn Reson Med 2002 47:1065-72
• JA de Zwart, P van Gelderen, P Kellman, JH Duyn
  Application of sensitivity-encoded echo-planar imaging for blood oxygen level-dependent functional brain imaging.
  Magn Reson Med 2002 48:1011-20
• JA de Zwart, PJ Ledden, P Kellman, P van Gelderen, JH Duyn
  Design of a SENSE-optimized high-sensitivity MRI receive coil for brain imaging.
  Magn Reson Med 2002 47:1218-27
• JA de Zwart, P van Gelderen, P Kellman, JH Duyn
  Reduction of gradient acoustic noise in MRI using SENSE-EPI.
  Neuroimage 2002 16:1151-5


• JA de Zwart, FC Vimeux, J Palussière, R Salomir, B Quesson, C Delalande, CT Moonen
  On-line correction and visualization of motion during MRI-controlled hyperthermia.
  Magn Reson Med 2001 45:128-37
• CT Moonen, B Quesson, R Salomir, FC Vimeux, JA de Zwart, JJ van Vaals, N Grenier, J Palussière
  Thermal therapies in interventional MR imaging. Focused ultrasound.
  Neuroimaging Clin N Am 2001 11:737-47, xi


• R Salomir, FC Vimeux, JA de Zwart, N Grenier, CT Moonen
  Hyperthermia by MR-guided focused ultrasound: accurate temperature control based on fast MRI and a physical model of local energy deposition and heat conduction.
  Magn Reson Med 2000 43:342-7
• R Salomir, J Palussière, FC Vimeux, JA de Zwart, B Quesson, M Gauchet, P Lelong, J Pergrale, N Grenier, CT Moonen
  Local hyperthermia with MR-guided focused ultrasound: spiral trajectory of the focal point optimized for temperature uniformity in the target region.
  J Magn Reson Imaging 2000 12:571-83
• B Quesson, JA de Zwart, CT Moonen
  Magnetic resonance temperature imaging for guidance of thermotherapy.
  J Magn Reson Imaging 2000 12:525-33


• FC Vimeux, JA De Zwart, J Palussiére, R Fawaz, C Delalande, P Canioni, N Grenier, CT Moonen
  Real-time control of focused ultrasound heating based on rapid MR thermometry.
  Invest Radiol 1999 34:190-3
• JA de Zwart, FC Vimeux, C Delalande, P Canioni, CT Moonen
  Fast lipid-suppressed MR temperature mapping with echo-shifted gradient-echo imaging and spectral-spatial excitation.
  Magn Reson Med 1999 42:53-9
• C Delalande, JA de Zwart, H Trillaud, N Grenier, CT Moonen
  An echo-shifted gradient-echo MRI method for efficient diffusion weighting.
  Magn Reson Med 1999 41:1000-8


• DP Madio, P van Gelderen, D DesPres, AW Olson, JA de Zwart, TW Fawcett, NJ Holbrook, M Mandel, CT Moonen
  On the feasibility of MRI-guided focused ultrasound for local induction of gene expression.
  J Magn Reson Imaging 1998 8:101-4


• JA de Zwart, P van Gelderen, DJ Kelly, CT Moonen
  Fast magnetic-resonance temperature imaging.
  J Magn Reson B 1996 112:86-90

Book Chapters

• JA de Zwart, JH Duyn
  Evolution of Instrumentation for Functional Magnetic Resonance Imaging.
  In: "Brain Mapping - An Encyclopedic Reference" (ISBN 978-0-12-397316-0) Arthur W. Toga (eds.) 2015 89-96
• CTW Moonen, JA de Zwart, FC Vimeux, J Palussière, N Grenier, P Voisin, A Vekris, P Canioni, P van Gelderen, J Pergrale, P Lelong, E Dumont, J van Vaals
  Towards real-time control of local hyperthermia based on fast MR temperature mapping.
  In: "Ultrafast magnetic resonance imaging in medicine" (ISBN 0-444-50280-7) Shoji Naruse, Hiroshi Watari (eds.) 1999 277-284

Patents

• CTW Moonen, R Salomir, F Vimeux, J de Zwart
  Ensemble de traitement thermique de tissus biologiques et procédé de mise en oevre de cet ensemble.
  Patent Number: WO 2001019457 A1 2000

Grants Received

• National Institutes of Health, NINDS competitive fellowship award
  Improved Functional MRI Using Multiple Surface Coils.
  Jan 1, 2002 - Aug 21, 2003
• European Commission, Marie Curie TMR research grant ERBFMBICT961733
  Ultra Fast Non Invasive Imaging of Temperature for Application In Gene Therapy and Tumor Ablation.
  Apr 1, 1997 - Mar 31, 2000